Record 01 Week of 5 October 2026 · REGULATION Six peptides recommended for the 503A bulks list · REGULATION From Category 2 to review: how twelve peptides came off the restricted list · REGULATION FDA proposes to end 503B compounding of semaglutide, tirzepatide and liraglutide · TRIALS Retatrutide: four Phase 3 readouts in 2026 · TRIALS Orforglipron approved; the oral GLP-1 question · PAPERS GLP-1 drugs recruit hunger neurons to sustain fat loss, Yale study finds · PAPERS A peptide–drug conjugate that hits five targets, in mice · PAPERS What GLP-1 users do differently: activity, bone and persistence · EVIDENCE BPC-157: what the human record contains · PUBLIC AND POLICY A public-health school explains the peptides in the feed · PUBLIC AND POLICY The gray market and the state patchwork · INDUSTRY Who makes peptides: capacity and ownership moves · Record 01 Week of 5 October 2026 · REGULATION Six peptides recommended for the 503A bulks list · REGULATION From Category 2 to review: how twelve peptides came off the restricted list · REGULATION FDA proposes to end 503B compounding of semaglutide, tirzepatide and liraglutide · TRIALS Retatrutide: four Phase 3 readouts in 2026 · TRIALS Orforglipron approved; the oral GLP-1 question · PAPERS GLP-1 drugs recruit hunger neurons to sustain fat loss, Yale study finds · PAPERS A peptide–drug conjugate that hits five targets, in mice · PAPERS What GLP-1 users do differently: activity, bone and persistence · EVIDENCE BPC-157: what the human record contains · PUBLIC AND POLICY A public-health school explains the peptides in the feed · PUBLIC AND POLICY The gray market and the state patchwork · INDUSTRY Who makes peptides: capacity and ownership moves ·

Topic primer

Mitochondrial

A small field built on peptides encoded in the mitochondrial genome. Most evidence is from animals and from measurements of circulating levels in people; regulatory interest arrived before clinical trials did.

TIMELINE

Sep 2023

MOTS-c placed in Category 2.
23–24 Jul 2026

PCAC recommends MOTS-c for the 503A bulks list, 7 to 5.

Mitochondrial

TIMELINE

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